We have all heard the warnings that the rate of avoidable medical errors is staggeringly high, with estimations of hundreds of thousands of preventable deaths annually in the US. Deaths from medical error has even been referred to by some as an epidemic. These reports have become viral in their reach by infiltrating the lay […]

Small cell lung cancer (SCLC) is a devastating diagnosis, and new therapeutic options are desperately needed in this setting. Previously, first-line treatment of extensive-stage SCLC was limited to combination chemotherapy, which is associated with modest overall survival (OS), but inroads have been made with the application of immune checkpoint inhibitor antibodies to this setting. Immunotherapy […]

On June 18, 2019, the United States Food and Drug Administration granted accelerated approval to the PD-1 inhibitor pembrolizumab for use as a monotherapy in the treatment of patients with metastatic small cell lung cancer (SCLC) with disease progression on or after platinum-based chemotherapy and at least 1 other line of therapy. This approval was […]

Chimeric antigen receptor (CAR)-modified T cells have become an important treatment option for some patients with hematologic malignancies, including non-Hodgkin lymphoma and acute leukemias. However, CAR T-cell treatment can be associated with cytokine release syndrome (CRS), which limits its utility by restricting administration only to experienced centers capable of managing this potentially fatal event. In […]

Mutation testing using cell-free (cf) DNA is becoming increasingly common in oncology, particularly as a tool in tumors that commonly have driver mutations, such as non-small cell lung cancer. Circulating cf tumor DNA in the plasma is now routinely being used alongside traditional tissue-based testing to guide treatment selection and detect resistance mutations upon progression. […]

According to a population study published recently in JAMA Oncology, cancer survivors are more likely to suffer from chronic pain and high-impact chronic pain than the general population. The study evaluated long-term outcomes among 4526 adult cancer survivors included in the US National Health Interview Survey. Chronic pain occurred in 1648 (34.6%) and high-impact chronic […]

On May 24, 2019, the United States Food and Drug Administration (FDA) granted approval to the phosphoinositide 3-kinase (PI3K) inhibitor alpelisib for use in combination with fulvestrant for treatment of women and men with hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2–) advanced breast cancer who carry PIK3CA mutations and have progressed on […]

Despite advances in cancer screening and detection, many cancers are not diagnosed until after they have metastasized. In patients with aggressive malignancies or severe comorbidities, survival can be limited. There has been relatively little information about treatment and outcomes in this population. To better understand treatment patterns in patients with poor prognosis, a study of […]

On May 13, 2019, the United States Food and Drug Administration (FDA) expanded the indication of the angiogenesis inhibitor ramucirumab to include use in patients with hepatocellular carcinoma (HCC) who have an alpha-fetoprotein (AFP) of greater than or equal to 400 ng/mL and have previously been treated with sorafenib. This decision was based on results […]

Immunotherapy with PD-1 and PD-L1 inhibitors has been a welcome addition to cancer treatment across numerous tumor types. While these agents are highly effective in some patients, they can be associated with severe, long-lasting adverse events (AEs). To better capture the incidence of AEs associated with PD-(L)1 inhibitors, a recent meta-analysis published in JAMA Oncology […]